The project "Development of diagnostics and treatment opportunities based on Alpha-fetoprotein and its receptor" is based on two “arms”:
1. development of AFP receptor measurement in biological fluids to detect a tumor (CA-62),
2. development of the drug delivery system based on native AFP, which as shown, can bring agent inside the tumor cell (OncoShuttle™) via receptor-mediated endocytosis.
Competitive advantages: We have the Know-How to create native AFP complexes, which can penetrate into tumor cells, and how to detect CA-62 in the blood and tissues.
Main point of the innovation: Usage of native AFP gives opportunity not only to bring the upload to tumor cell but to use receptor-mediated endocytosis and put it inside the cell. Measurement of CA-62 allows to select patients to be cured. Monitoring of CA-62 marker also makes evaluation of treatment possible.
Market potential - More than $1 billion
IP protection potential - Know-How and Patents
Exit strategy - Strategic Partnering
Stage of the project - Clinical studies
The Members of Our International Team
Ricardo Moro and Viatcheslav Kondratiev hands shaking after signed agreement
Moro M.D. (Canada)
- scientist, doctor, honored researcher of Science, member of the editorial
board of the scientific journal Tumor Biology, President of the International
Society of Oncology and Biomarkers (ISOBM). Worked for a time as a full time researcher of the French National Cancer Institute (Institut de Recherches Scientiliques sur le Cancer, Villejulf, France, which was part of the CNRS (Centre National de la Recherche Scientifique) and was in part supported by the Association pour la Recherche sur le Cancer (A.R.C.)). Further the French Cancer Institute was absorbed by the Pasteur Institute.
Kondratiev M.Sc. (Canada/Russia), alumni of the
Schulich School of Business of the York
University, Toronto. Under his
leadership the technology OncoShuttle has been developed and patented in the
U.S., Europe and Russia (2011-15). He is a CEO of
the UCT (Universal Cancer Technologies) Research And Development.
Janneta Tcherkassova Ph.D. (Canada/Russia)-Internship in Sweden, member of the International Society of Oncology and Biomarkers (ISOBM), head of the tumor markers laboratory at the Skolkovo Innovation Center, Moscow, Russia. For 13 years she worked in Canada as a head of the Department of Diagnostics. Under the leadership of Dr. Moro since 2003, developed approaches for test for early cancer detection. Beginning 2014 develops test in Russia as coordinator of laboratory test development. About 20 scientific publictions.
Sergei Tsurkan and Stéphane Gagné at the ENA2018 conference, Dublin, Ireland
Stéphane Gagné, MBA, Sherbrooke University (Canada) cumulates over 20 years of experience in the fields of cosmetics, nutritional supplements, cancer pharmaceutical products. He holds two bachelor degrees and a Master in Business Administration. He has held senior positions in biotech companies ( Ovensa, Aeterna Laboratories, Atrium Innovations etc.). Mr. Gagné has played a significant role in the growth of several Canadian companies abroad through his network of contacts in North and South America, Europe and Asia.
Sergei Tsurkan, Ph.D., MBA, strong economic and scientific background. The experience in scientific, product and marketing development of several pharmaceutical companies (Sotex, Drugs technology, Maxpharm). Sergei is in charge in supervising and management with Aimpila preclinical development, CA-62-test transfer and development. He has over 23 scientific publications.
Vera Gorbunova, Dr.M., professor (Russia/USA)- one of the famous Russian scientists and practical doctor in the field of tumor desease chemotherapy. More than 400 hundred articles, Hirsh index is 34. Member of the Cancer Society of Russia (1971); European Society of Medical Oncologists (1991); French Federation of Oncology (1997); New York Academy of Sciences (1997); American Society of Clinical Oncology (1999) and others; honored with State Prize (2002).
Vera Gorbunobva helps our team in the field of clinical approach in development of our products.
Head of the Laboratory of Radionuclide and Radiation Technologies in Experimental Oncology of the Russian Cancer Research Center.
2004 - Awarded I.V. Kurchatov premia for the best fundamental work, Membership in leading scientific communities: Association of Oncologists of Russia, Nanotechnological Society of Russia, Oncological Society of Molecular Visualization, Association of Medical Physicists of Russia. Elena has published about 80 articles.
Yelena helps us in pharmacokinetics studies and preclinical development
Helen helps us in studying of comparative activity of our complexes.
Evgueni Klinski Ph.D. (Canada/Russia) - member of American Associations of Pharmaceutical Scientists (AAPS), American Chemistry Society (ACS) and Control Release Society (CRS). He has more than 20 years of wide experience in Canadian industrial pharmaceutical company, such as formulation development, pharmacokinetics/pharmacodynamics and drug metabolism.
Evgueni helps us in the field of proteins isolation. He is in charge in international know-how and technology transfer.